- Heimerdinger was designed by Ezreal (person).
- Heimerdinger is voiced by Dennis Collins Johnson, Who also voices Gangplank and Taric.
- His name is a combination of the names of J. Robert Oppenheimer, a physicist known for being the "father" of the atomic bomb, and Erwin Schrödinger, one of the fathers of quantum physics.
- Heimerdinger has the lowest armor of all champions at level 18. (61)
- Heimerdinger can have 3 turrets out utilizing a glitch with Syndra's Force of Will Force of Will by placing 2 turrets and having one picked up. During the stasis Heimerdinger can place a turret and will have 3 once the effect from Force of Will Force of Will ends.
- His walking quote "For great science" is a reference to the internet meme "For great justice", which originated from the Engrish translation of the game Zero Wing.
- His other walking quote, "Back, you dirty ape, back!" is a reference to Planet of the Apes.
- Rumble's League Judgment contains a quote from Heimerdinger, who insults him in a technical manner: "The probability of your continued existence is rapidly approaching zero."
- Alien Invader Heimerdinger is a reference to Mars Attacks!, a comedic alien invasion movie.
- The skin changes the look of his turrets to retro sci-fi rayguns.
- Piltover Customs Heimerdinger changes the look of his turrets to engines.
- The skin's art background has the Hot Rod Corki flying vehicle.
- Blast Zone Heimerdinger's Chinese artwork is used as an image to show that the League of Legends store is under maintenance.
- Heimerdinger created Master Yi's goggles, the Seven Lenses of Insight.
- Heimerdinger also created Corki's Reconnaissance Operations Front-Line Copter (ROFL copter).