Varus shares a similar style to that of Irelia death, curiously both are Ionians and are killed by their own weapons.
Varus' body style is similar to the one of Solus, the T'Lan leader from the game Breakdown.
Varus' lore and namesake could be a slightly inverse reference to the infamous Roman general Publius Quinctilius Varus, who foolishly led three Roman legions to their demise during the Battle of Teutoburg Forest. However, the Roman Varus commits suicide before he could be captured by the defending (albeit ambushing) Germans, while the Varus of League's lore defends his charge but loses everything to the Noxian invaders, to which he vows revenge.
Varus is the only champion since Graves to receive a League Judgement.
Classic Varus wields his bow with his left hand, despite the splash art suggesting he wields it with his right hand. It could mean that he is simply ambidextrous, as he switches his bow between hands when he dances.
Blight Crystal Varus might be a reference to the MMORPG World of Warcraft, where the undead would use Blight Crystals alike to the ones on the art to corrupt other creatures.
Arclight Varus is the second light themed skin for two dark themed Ionian Champions. The first being Justicar Syndra.
It is also what Varus would've looked like if he had not allowed himself to be corrupted by the Pit of Pallas.
Varus is also equipped with bow similar to one wielded by Pit on the beginning of Kid Icarus: Uprising video game, they both also share similar clothes design.
The city in the splash art bares a resemblance to the ruins floating around the Savior, the final boss of Devil May Cry 4