It is also important to note that some runes are "primary", while others are called "secondary" and provide lesser bonuses. Given a certain kind of rune, it will be primary in either marks, glyphs or seals, and secondary in the other two rune types.
Although Quintessences have the max possible effect, you may only have three instead of the nine marks, seals, or glyphs - this means one quintessence should be equal to three or more runes in order to qualify as a "Primary" Quintessence. The following Quintessences have an effect equal to or greater than three primary runes: Avarice (Gold / 10 sec), Clarity (Mana Regen / 5 sec per level), Endurance (Health %), Fortitude (Health), Intellect (Mana), Potency (Ability Power), Replenishment (Mana Regen / 5 sec), Resilience (Armor), Vigor (Health Regen / 5 sec).
Runes that have already been purchased can't be sold back to the store, but can be combined in the Rune Combiner for a new rune of random stats. Tier 1 and Tier 2 runes do not grant as high bonuses as Tier 3 runes and a player may end up just combining the lower quality runes for Tier 3 runes anyway. Therefore it is wise to save up Influence Points for Tier 3 runes. There are two ways to combine:
Combine five runes to create one random rune of higher tier.
Combine two runes to create one random rune of the same tier. NOTE: It is possible for the Rune Combiner to produce a rune of the exact type as one of the input runes, costing you one rune and gaining you nothing.
It is important to note that you cannot buy a Tier 3 rune before you reach level 20, and that you can acquire random ones for less IP than buying them outright by using the Rune Combiner.
Five "Lesser Seals of Replenishment" cost 75 IP (5 × 15 IP), while one "Seal of Replenishment" costs 80. This equates to a saving of 5 IP.
Likewise, a combined Tier 3 rune would cost 375 IP (25 × 15 = 5 × 75), cheaper than Tier 3 runes of costs from 410 to 2050 IP. This equates to a saving of 35 IP minimum and 1675 IP maximum.
The cheapest Tier 3 rune costs 205. This equates to a 170 IP loss.
Keep in mind that combining 5 runes of one type will not guarantee you a better (Primary) rune of that same type. The Rune Combiner may also give you a Secondary Rune.
It is possible to combine runes to higher tiers and use them freely even if you are too low a level to buy them directly. However, it is not recommended, as most runes aren't that helpful (e.g. destruction runes, which are very specific, or secondary runes), thus the best long term strategy is to start buying them at level 20 and saving up Influence Points before then.
Summoners are able to use a rune per level of power in League of Legends, and they keep their Runes in a tome called a Runebook. Before a match begins, a Summoner will be able to choose from up to twenty different rune configurations they have previously set in their Runebook. This allows the Summoner to have quick flexibility in choosing a Runebook configuration best suited for whatever champion they might use in any of Valoran's Fields of Justice.