Cho'Gath's name is likely derived from "Shoggoth," an otherworldly monster from the works of H.P. Lovecraft. The two are similar in that they are alien to the world they reside in (Valoran/Earth), but otherwise they do not share much similarities.
Cho'Gath is the second champion to receive a second legendary skin after Corki.
Cho'Gath's dance is the same as Mickey Mouse's dance in Disney's Fantasmic! show at Disneyland.
Cho'Gath ties for highest base damage at level 18 with Skarner (130).
The icon used to indicate the Tenacity stat on champions is the same icon of his Vorpal Spikes icon.
The blueprints for Battlecast Prime Cho'Gath shows five "file names" at the top right with the names XER, URG, SKA, MAW and ANV. This is likely a hint at the other Battlecast skins to come.
Under a forum thread that discussed the cancelation of 20pxOmen, Zileas noted that, in a skins meeting, someone once suggested a "Japanese Schoolgirl" or "Magical Girl" skin for Cho'Gath, and that he supports its creation.