- Ryze was designed by Ezreal and Guinsoo.
- Ryze is one of five champions voiced by Adam Harrington, the other four being Karthus, Kassadin, Mordekaiser, and Shaco.
- Desperate Power's development function "While Ryze's health is low, his ability power is increased" is now the passive ability for Karma.
- He was the first champion released prior Season One to obtain a League Judgement.
- Ryze's original cost was 1350 . He was lowered to 450 on April 12, 2011.
- Human Ryze is one of the four Collector's Edition skins, the other champions with this distinction are Alistar, Kayle and Annie. It can no longer be obtained, as it was a pre-order skin.
- Uncle Ryze is a reference to Uncle Sam used in United States army recruitment.
- In the Chinese Uncle Ryze art, The Declaration of Independence that Ryze carries on its back is replaced with other text.
- Tribal Ryze is often compared/considered to look like Zeus, the God of the Sky and Ruler of the Olympian gods, from Greek Mythology.
- Triumphant Ryze is only available to those who win official competition matches. The skin was previously known as "Champion" and "Trophy".
- Pirate Ryze's splash art features several other champions that share the pirate theme. From left to right, these champions are: Bilgerat Rumble, Fiddle Me Timbers, Bilgewater Katarina, Buccaneer Tristana and Bilgewater Swain.