Level Transfusion to level 5, as it is Vladimir's most constant single target damage ability, as well as his heal. Remember that the base healing component is a flat amount modified by additional ability power, so even if the target is not damaged (i.e. shielded, blocked by Banshee's Veil, or blocked by 凯尔的Intervention), you will still be healed by the ability.
When using 弗拉基米尔的Transfusion, you won't be healed until the particle returns to you.
Having at least 1 rank of Sanguine Pool can help you survive for much longer, as it resets aggro. A skilled player can use it to turret dive or to dodge abilities. However, it has a long cooldown and a short duration, so do not become too reliant on it for escapes.
It is wise to use Sanguine Pool to chase down an enemy or escaping from one. Using it as a damage skill could leave you extremely vulnerable if you can't kill the enemy.
While Vladimir cannot use any abillities during Sanguine Pool, if Ghost is used before using Sanguine Pool, Vladimir will still receive the movement speed bonus making it a very viable escape maneuver. Conversely, if Vlad is slowed before going into pool, he will still be slowed during the pool.
During Sanguine Pool he becomes untargetable to both enemy and allied champions.
Tides of Blood can be cast without having any enemy targets nearby. This can allow you to keep the buff constantly active or build stacks to prepare for an attack. It can also increase the effectiveness of a Health Potion if used prior to activating it. Additionally, using it when a stealthed enemy is nearby will allow you to detect them, they will not destealth, but you will be able to see the missiles flying into their direction. This also works if an enemy is concealed in brush nearby.
Gaining stacks of Tides of Blood prior to a gank can result in devastatingly high nuking ability upon multiple enemies. For the same reason, Vladimir damage output rises exponentially after about 10 seconds during team fights as his stacks increase very quickly, which can result in massive AoE damage when combined with Hemoplague.
Hemoplague causes targets to take bonus damage, so it is advised to use it at the beginning of team fights to increase the overall damage your team can inflict upon your enemies. Mid to late game, Banshee's Veil will negate both the increased damage debuff and the 5 second delayed damage component, make sure to spend as many of the opposing team's charges prior to activating.
Hemoplague can take time to learn when to cast. The most important aspect of timing this ult is making sure you cast it when the enemy has committed to the fight. Often, if you lead with it, the enemy team will disengage and your ult will have had little to no impact.
Hemoplague can be used to finish off a target low on health. The range to the edge of the AoE is deceptively long; keep this in mind when deciding whether to pursue a target near death.
When using Hemoplague, be wary of champions who can counter the delayed damage, such as those with shields or heals. Do not depend on it to ensure your kill.
Casting Hemoplague will not deal any immediate damage, and therefore can be used to kill low health enemies under their turret.
Vladimir can be built as a tanky caster due to Crimson Pact by building health and AP items. Like most AP champions, it is better to focus on AP and CDR, and neglect armor and magic resist, unless the enemy has % hp based damage.
It's generally advised to get Ionian Boots of Lucidity because Vladimir greatly benefits from CDR and has very limited options of CDR items as a manaless AP.
Rabadon's Deathcap is one of the most popular items on spell casters. On Vladimir, thanks to his Crimson Pact, it also gives him 254 HP and the 30% bonus AP gained interacts with his passive.
Hextech Revolver, and later, Will of the Ancients, is the most important item on Vladimir since it will increase the amount healed with Transfusion as well as adding a healing component to the rest of his abilities and increasing his maximum health due to his passive. The spell vamp compensates for the cost of 2 of his abilities, as they use health to cast.
Haunting Guise is a stronger item for Vladimir than other AP Champs because he gains AP from the 250 HP it gives. It's a strong item for mid game for most AP champs, but even better on Vlad.
Rylai's Crystal Scepter is a great item for most casters, but Vladimir will benefit even more from it due to his lack of CC and range as well as his passive: it will grant 612 HP and 92.5AP instead of 500 HP and 80 AP. Additionally, the passive gives his spells constant slows.
Spirit Visage will improve all healing/spell vamp for Vladimir, making it a strong item.
Deathfire Grasp is a useful item for it's active can be amplified by his ultimate.
Abyssal Scepter is one of Vlad's best items. It grants him tremendous defense and offense.
Remember that Transfusion doesn't heal Vlad until the particle returns to him, and because the animation is two-staged (impalement, then return), most single-target projectiles like Two-Shiv PoisonTwo-Shiv Poison, Vorpal Blade, and Null Sphere will generally hit him before he's healed. This is useful to remember should you be uncertain about last-hitting him.