Orianna bears some similarities to GLaDOS from the Portal series, both in voice acting and in personality.
The word "Orianna" is a European name and has a few possible origins. They all seem to refer to the "golden color of the sun":
"Orianna" is the Irish meaning of "Blonde" or "Golden".
The name may also be from the medieval Spanish and Portuguese word "Oroana/Ouroana" (which also means "Golden").
Another possible origin is from the Latin meaning of "Rising" (as in, "Sunrise").
The term "Clockwork" refers to the inner workings of either a mechanical clock or a device that operates in a similar fashion. Specifically, a mechanical device utilizing a complex series of gears, such as an automaton.
Orianna's title was originally "The Clockwork Girl", but was then changed to "The Lady of Clockwork" the night before her release. This was due to a film that is in the making called "The Clockwork Girl".
Orianna's joke "When you fall, you get right back up." coincides with Aigis' line. Aigis is a female robot character from the game Persona 3 who says these words when she is hit by an attack she is weak against.
The quote "I know what makes them tick. I know how to make the ticking stop." is a paraphrased reference to the character Sylar from the now-cancelled NBC show Heroes, more specifically him describing his super-power. This is also a reference to the Magic the Gathering card Organ Grinders flavor text.