Be careful when using Ambush near enemy turrets, as turrets can see invisible units.
It is always good to use Ambush to scout brushes and to look for enemies.
Twitch can be very good at chipping away an opponent's health with the true damage from his passive. After hitting an opponent a few times, throw your poison vial (W) to hit enemies at long range and add two poison ticks, but more importantly to extend the amount of time they are taking damage from your poison.
图奇的Ambush has a timer. Watching the timer is very important when using stealth. Twitch is very good at scouting ahead of his allies while stealthed.
Play cautiously around characters with crowd control. Twitch's low health makes him especially vulnerable to bursts of damage.
Be careful of enemy champions who have a Vision Ward or the Oracle's Elixir as well as champions who have abilities that can detect stealth, such as 莫甘娜的Soul Shackles. This makes Twitch unable to scout safely or move close enough for a kill.
Buying an Oracle's Elixir of your own allows you to counter enemy Vision Wards, but simply playing less aggressively can prevent getting hurt or killed by enemies who are using stealth-countering abilities or items and gives you the advantage in gold.
Spray And Pray is a very good ability to use during teamfights, because you can hit all 5 members of the opposing team.
At high levels and assuming that you are a skilled Twitch player and a skilled jungler, you can move Twitch into the jungle. He is weak when it comes to farming in the jungle for long periods of time, however, his ganks with red buff go unparalleled.
Twitch can function as a attack damage carry in bot lane as well, and is best supported by a character that can hold the lane 1v2 while he ganks.
When ganking, Ambush should be used early, so as not to be caught by regular wards on your way over. When you arrive at your destination, if your stealth timer is low, sit in a bush and wait to re-stealth prior to jumping on your opponent.
At the start of the match, try waiting until the enemy jungler finishes killing blue, then kill him. If successful, this provides a substantial early game lead and can shut down junglers that scale into late game(Amumu, Olaf, etc.).
If you take Ambush first, use it sparingly so that you don't run out of mana early game.
Taking Ambush early game allows Twitch to check bushes without taking too much damage and allows him to counter jungle more efficiently.
If you take Expunge first, use the damage to farm effectively. Do not use it to harass unless you have six stacks of Deadly Venom otherwise you will run out of mana trying to harass and farm at the same time.
Twitch'sattack speed is among the highest in the game, allowing you to focus on other offensive stats.
Infinity Edge is a highly recommended item to obtain first, granting the damage and critical strike-related stats Twitch lacks.
Try purchasing items that provide a variety of stats for defense/offense, such as Wit's End for magic resistance and The Black Cleaver for armor penetration, both important stats for twitch while giving him damage/attack speed.
Madred's Bloodrazor, however, doesn't work well with Twitch due to his focus on physical damage, not on-hit effects, and is too expensive to be worth the cost. Anyway, your role is to spike down weak targets quickly, not focus the beefy ones.
Using lifesteal also helps with Twitch's small health pool, although when using your ultimate, you will only receive a third of the usual lifesteal per target.
Tiamat combined with Spray And Pray can lead Twitch to a massive AoE damage in team fights, since each missile from Spray And Pray will splash with Tiamat allowing you to hit a single target multiple times if the target is surrounded by other enemy units.