All of Karma's abilities have both an offensive and a defensive component, accentuating the dualism of her character.
Her black and white robes display this as well, possessing a black and white side.
Karma was the first champion to feature an art spotlight even before her official arrival.
The name Karma, and the title, "The Enlightened One" is related to the Buddha, which is Sanskrit for "enlightened one." The doctrine of karma, the effects good or bad actions have on a person, is prominent in Buddhist, Hindu, Jain and Sikh beliefs.
Karma is the only champion whose three main abilities have six ranks.
According to the voice actress, she fused accents of Storm from X-Men and Gaia from Captain Planet to create Karma's voice.
Karma is the second champion after Udyr to lack an upgradable ultimate skill. Unlike Udyr, Karma is still in possession of an ultimate skill, although it cannot be activated directly.
Karma is possibly based off Indian backgrounds because her ultimate Mantra is also a naturally occuring force that means "creation of the mind", in the Indian beliefs. Also her name "Karma" literally means "what goes around comes around" (similar to Yin and Yang in Chinese) in Indian language.
Karma's quotes,"An enlightened decision," "Onward always", "To conquer oneself is to conquer all", "Peace begins within" and "I interrupted my meditation for this?" all have connection to Buddhist beliefs.
Karma's joke "Guess what's about to hit the fan" is a reference to the saying "the sh*t hits the fan"; it means that something is about to change radically, like a situation escalating. This has a 30% chance of having her say it in-game